منابع مشابه
Clinical xenotransplantation.
Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies ...
متن کاملLiver xenotransplantation.
During the past 30 years orthotopic liver transplantation has become a highly successful form of surgical treatments. The significant advances achieved in this field have led to an increased demand for organs and created a wide gap between organ availability and organ supply. A wider availability of organs for transplantation would allow an expansions rather than a contraction of the indication...
متن کاملKidney Xenotransplantation
Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process involving preformed and elicited antibodies, heig...
متن کاملXenotransplantation: Today and Tomorrow
Xenotransplantation using pig cells, tissues or organs is at present thought to be the best approach to alleviate the increasing shortage of human tissues and organs for the treatment of tissue and organ failure. This shortage is the reason that approximately 25% of the patients on a waiting list die before they could be treated with an appropriate donor organ. In the US, 30,974 organ transplan...
متن کاملProspects of clinical xenotransplantation.
OUR two recent atte~pts ~t baboon-to-human xenotransplantatton faJled. I -. However. there were encouraging notations. First. the xenografts had no evidence of B virus infection during their posttransplant survival of 70 and 26 days in B virus carriers. Second. there also was little histopathologic evidence of humoral or cellular rejection of these livers. Yet. their function was suboptimal. If...
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ژورنال
عنوان ژورنال: Circulation
سال: 1998
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.97.15.1431